Lowman attended New York University, where he studied art and graduated with a Bachelor of Fine Arts in 2001. His education and subsequent career have been deeply intertwined with the New York contemporary art scene, particularly through his affiliations with the influential gallery scene in Lower Manhattan.
His art is characterized by the use of everyday materials and found images, repurposing icons of mass media into critiques or explorations of modern American life. Lowman's works frequently incorporate elements such as smiley faces, bullet holes, and tabloid headlines, transforming them into pieces that comment on the banality and brutality of American culture.
Lowman's notable exhibitions include his participation in the Whitney Biennial and shows at prominent venues like the Palazzo Grassi in Venice and the Guggenheim Museum. His work has been discussed in terms of its approach to the detritus of pop culture and its critique of the glamour and superficiality of celebrity culture.